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Invitrogen
SH3PXD2A Polyclonal Antibody
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FIGURE: 1 / 4
SH3PXD2A Antibody (PA5-58169) in WB
Western blot was performed using Anti-SH3PXD2A Polyclonal Antibody (Product # PA5-58169) and ~130 kDa band corresponding to SH3PXD2A was observed in HeLa and A-375 cells and not in SK-BR-3 which is reported to be negative. Membrane enriched extracts (30 µg lysate) of HeLa (Lane 1), A-375 (Lane 2) and SK-BR-3 (Lane 3) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001... View More
Product Details
PA5-58169
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SH3PXD2A. Recombinant protein control fragment (Product #RP-97054).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PDPSGKELDT VPAKGRQNEG KSDSLEKIER RVQALNTVNQ SKKATPPIPS KPPGGFGKTS GTPAVKMRNG VRQVAVRPQS VFVSP
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 88%.
Target Information
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adapter protein TKS5; adaptor protein TKS5; Five SH3 domain-containing protein; five SH3 domains; KIAA0418; SH3 and PX domain-containing protein 2A; SH3 multiple domains 1; SH3 multiple domains protein 1; Tyrosine kinase substrate with five SH3 domains; unnamed protein product
Gene Aliases: 2310014D11Rik; AA589508; AI256723; AI413738; C230050L11; EG329070; FISH; Gm5098; KIAA0418; SH3MD1; SH3PXD2A; TKS5; TSK5
UniProt ID: (Human) Q5TCZ1, (Mouse) O89032
Entrez Gene ID: (Human) 9644, (Rat) 309460, (Mouse) 14218
protease binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-5-phosphate binding
superoxide-generating NADPH oxidase activator activity
phosphatidylinositol-3-phosphate binding
phosphatidylinositol binding
phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol-4-phosphate binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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