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Invitrogen
Girdin Polyclonal Antibody
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Product Details
PA5-58246
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Girdin. Recombinant protein control fragment (Product #RP-96013).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TPGDFYDRRT TKPEFLRPGP RKTEDTYFIS SAGKPTPGTQ GKIKLVKESS LSRQSKDSNP YATLPRASSV ISTAEGTT
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 87%.
Target Information
Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Akt phosphorylation enhancer; AKT-phosphorylation enhancer; APE; Coiled-coil domain-containing protein 88A; G alpha-interacting vesicle-associated protein; Girders of actin filament; girders of actin filaments; Girdin; GIV; HkRP1; Hook-related protein 1
Gene Aliases: APE; CCDC88A; GIRDIN; GIV; GRDN; HkRP1; KIAA1212
UniProt ID: (Human) Q3V6T2
Entrez Gene ID: (Human) 55704
regulation of protein phosphorylation
DNA replication
regulation of DNA replication
regulation of neuron projection development
cell migration
lamellipodium assembly
TOR signaling
activation of protein kinase B activity
regulation of actin cytoskeleton organization
regulation of cell proliferation
membrane organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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