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Invitrogen
Girdin Polyclonal Antibody
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Product Details
PA5-58246
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Girdin. Recombinant protein control fragment (Product #RP-96013).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TPGDFYDRRT TKPEFLRPGP RKTEDTYFIS SAGKPTPGTQ GKIKLVKESS LSRQSKDSNP YATLPRASSV ISTAEGTT
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 87%.
Target Information
Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-7 gene product; Akt phosphorylation enhancer; AKT-phosphorylation enhancer; APE; Coiled-coil domain-containing protein 88A; G alpha-interacting vesicle-associated protein; Girders of actin filament; girders of actin filaments; Girdin; GIV; HkRP1; Hook-related protein 1; unnamed protein product
Gene Aliases: APE; CCDC88A; GIRDIN; GIV; GRDN; HkRP1; KIAA1212; PEHO; PEHOL
UniProt ID: (Human) Q3V6T2
Entrez Gene ID: (Human) 55704
G-protein alpha-subunit binding
actin binding
protein kinase C binding
guanyl-nucleotide exchange factor activity
GDP-dissociation inhibitor activity
epidermal growth factor receptor binding
insulin receptor binding
microtubule binding
phosphatidylinositol binding
SH2 domain binding
protein homodimerization activity
vascular endothelial growth factor receptor 2 binding
protein kinase B binding
protein serine/threonine kinase activator activity
dynein light intermediate chain binding
signal transduction
small GTPase mediated signal transduction
nervous system development
regulation of neuron projection development
cell migration
cell projection organization
lamellipodium assembly
cytoskeleton-dependent intracellular transport
cytoplasmic microtubule organization
TOR signaling
activation of protein kinase activity
regulation of actin cytoskeleton organization
regulation of cell proliferation
positive regulation of cilium assembly
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of stress fiber assembly
positive regulation of protein kinase B signaling
membrane organization
maintenance of protein location in plasma membrane
positive regulation of protein localization to cilium
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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