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Immunogen sequence: SGSVAQLQGG NDTGTDEELE TGPEQKGCFS YQNSPGSHLS NQDAENESLL SDASDQVSDI KSVCGRDASD KKAHTHVRLP NEAHNCMDKM TAVYANILSD SYWSGLGLGF KLSNSERRNC DTRNGSNKSD FDWHQDALSK
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 90%.
The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. In mice, the known three TSHZ proteins are expressed in distinct patterns in the developing and adult brain, suggesting that they play a role in the establishment of regional identity and specification of cell types within the brain. Recent experiments have shown that the expression of TSHZ2 is frequently downregulated in most breast and prostate cancers and its promoter was unmethylated in virtually all cases, suggesting this family of proteins may also be involved in carcinogenesis.
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