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Invitrogen
TCOF1 Polyclonal Antibody
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Product Details
PA5-58309
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TCOF1. Recombinant protein control fragment (Product #RP-96814).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ESSRISDGKK QEGPATQVSK KNPASLPLTQ AALKVLAQKA SEAQPPVART QPSSGVDSAV GTLPATSPQS TSVQAKGTNK LRKPK
Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 32%.
Target Information
Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport. The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain. Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development. Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: nucleolar trafficking phosphoprotein; Treacher Collins syndrome protein; Treacher Collins-Franceschetti syndrome 1; Treacle protein
Gene Aliases: MFD1; TCOF1; TCS; TCS1; treacle
UniProt ID: (Human) Q13428
Entrez Gene ID: (Human) 6949
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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