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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: ERDPSVLYQY QPHGKRQSSV TVVSQYDNLE DYHSLPQHQR GVFGGGGMGT YVPPGFPHPQ SRTYATALGQ GAFLPAELSL QHPETQIHAE
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Brain-specific Rho GTPase-activating protein; GAB-associated Cdc42/Rac GTPase-activating protein; GC-GAP; GTPase regulator interacting with TrkA; p200RhoGAP; p250GAP; Rho GTPase-activating protein 32; Rho-type GTPase-activating protein 32; Rho/Cdc42/Rac GTPase-activating protein RICS; RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling
Gene Aliases: ARHGAP32; GRIT; KIAA0712; RICS
Entrez Gene ID: (Human) 9743
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