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Invitrogen
WDR24 Polyclonal Antibody
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Product Details
PA5-58820
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human WDR24. Recombinant protein control fragment (Product #RP-97604).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EQFVEKLNLR VGRKPSLNLS CADVVWHQMD ENLLATAATN GVVVTWNLGR PSRNKQDQLF TEHKRTVNKV CFHPTEAHVL LSGSQDGFMK CFDLRRKDSV ST
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
WDR24, as a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. WDR24 is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GATOR complex protein WDR24; GATOR2 complex protein WDR24; unnamed protein product; WD repeat-containing protein 24
Gene Aliases: C16orf21; JFP7; WDR24
UniProt ID: (Human) Q96S15
Entrez Gene ID: (Human) 84219
cytoplasmic translation
autophagy
regulation of autophagy
positive regulation of macroautophagy
protein ubiquitination
cellular response to nutrient levels
positive regulation of TOR signaling
cellular response to amino acid starvation
TORC1 signaling
negative regulation of translational initiation
positive regulation of translational initiation
protein localization to lysosome
protein K6-linked ubiquitination
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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