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Invitrogen
CCBE1 Polyclonal Antibody
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Product Details
PA5-59534
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CCBE1. Recombinant protein control fragment (Product #RP-98285).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CECREGYIRE DDGKTCTRGD KYPNDTGHEK SENMVKAGTC CATCKEFYQM KQTVLQLKQK IALLPNNAAD LGKYITGDKV LASNTYLPGP PG
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 90%.
Target Information
The gene encoding CCBE1 (Collagen and calcium-binding EGF domain-containing protein 1) is located on chromosome 18 in a region that is frequently found to be deleted in breast and prostate cancers. CCBE1 is a 406 amino acid secreted protein that contains two collagen-like domains and one calcium-binding epidermal growth factor (EGF-like) domain. In general, EGF-like domains include six cysteine residues that are usually involved in disulfide bonds. Calcium-binding EGF-like domains are subject to amino acid substitutions that disrupt their structure or calcium affinity, therefore altering protein function. Downregulation of the gene encoding CCBE1 is observed with high frequency in breast cancer, suggesting that loss of CCBE1 results in changes in cell adhesion and mobility due to its characterization as an extracellular protein. There are three named isoforms of CCBE1 which are produced as a result of alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Collagen and calcium-binding EGF domain-containing protein 1; FLJ30681; Full of fluid protein homolog; MGC50861
Gene Aliases: CCBE1; HKLLS1; KIAA1983; UNQ1921/PRO4395
UniProt ID: (Human) Q6UXH8
Entrez Gene ID: (Human) 147372
angiogenesis
lymph vessel development
lymphangiogenesis
sprouting angiogenesis
respiratory system process
respiratory gaseous exchange
positive regulation of vascular endothelial growth factor production
positive regulation of endothelial cell migration
positive regulation of protein processing
lung development
endothelial cell migration
positive regulation of angiogenesis
venous blood vessel morphogenesis
positive regulation of vascular endothelial growth factor signaling pathway
positive regulation of lymphangiogenesis
lymphatic endothelial cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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