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Invitrogen
RIC8A Polyclonal Antibody
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Product Details
PA5-59590
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RIC8A. Recombinant protein control fragment (Product #RP-97511).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TGEEDVIMEA LRSYNQEHSQ SFTFDDAQQE DRKRLAELLV SVLEQGLPPS HRVIWLQSVR ILSRDRNCLD PFTSRQSLQA LACYADISVS EGSVPESADM DVVLES
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 77%.
Target Information
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chaperone Ric-8A; MGC104517; MGC131931; MGC148073; MGC148074; resistance to inhibitors of cholinesterase 8 homolog A; RIC8 protein; Synembryn-A; unnamed protein product
Gene Aliases: RIC8; RIC8A
UniProt ID: (Human) Q9NPQ8
Entrez Gene ID: (Human) 60626
in utero embryonic development
vasculature development
protein folding
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
gastrulation
visual learning
response to light stimulus
cell migration involved in gastrulation
cell-cell adhesion involved in gastrulation
basement membrane organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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