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Invitrogen
NSMCE1 Polyclonal Antibody
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Product Details
PA5-59625
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NSMCE1. Recombinant protein control fragment (Product #RP-98763).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RRMGVMTDVH RRFLQLLMTH GVLEEWDVKR LQTHCYKVHD RNATVDKLED FINNINSVLE SLYIEIKRGV TEDDGRPIYA LVN
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
Target Information
The NSMCE1 (Non-SMC Element 1 Homolog) gene encodes a protein that is a key component of the SMC5-SMC6 complex, which is essential for DNA repair and the maintenance of genomic stability. Located on chromosome 16, the NSMCE1 protein interacts with other components of the SMC5-SMC6 complex, including SMC5, SMC6, and NSMCE2, facilitating the repair of DNA double-strand breaks and promoting chromosome segregation during cell division. NSMCE1 is particularly involved in homologous recombination, a critical pathway for error-free DNA repair. Mutations or deficiencies in NSMCE1 can lead to genomic instability, increased sensitivity to DNA-damaging agents, and have been associated with several genetic disorders and cancer predispositions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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