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Invitrogen
IST1 Polyclonal Antibody
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Product Details
PA5-59738
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human IST1. Recombinant protein control fragment (Product #RP-98777).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: APRLQSEVAE LKIVADQLCA KYSKEYGKLC RTNQIGTVND RLMHKLSVEA PPKILVERYL IEIAKNYNVP YEPDSVVMAE APPGVETDLI DVGFTDD
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
Target Information
Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Charged multivesicular body protein 8; CHMP8; hIST1; increased sodium tolerance 1 homolog; IST1 homolog; IST1, endosomal sorting complex required for transport-III component; IST1, ESCRT-III associated factor; KIAA0174; MGC117220; overexpressed in lung cancer 1; pm28; Putative MAPK-activating protein PM28; unnamed protein product
Gene Aliases: CHMP8; IST1; KIAA0174; OLC1
UniProt ID: (Human) P53990
Entrez Gene ID: (Human) 9798
protein localization
protein transport
multivesicular body assembly
establishment of protein localization
positive regulation of proteolysis
collateral sprouting
positive regulation of collateral sprouting
cell division
cytoskeleton-dependent cytokinesis
midbody abscission
ESCRT III complex disassembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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