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Invitrogen
C19orf66 Polyclonal Antibody
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Product Details
PA5-59815
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human C19orf66. Recombinant protein control fragment (Product #RP-99101).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KFHGKASSKK AGALMRKFGS DHTGVGRSIV YGVKQKDGQE LSNDLDAQDP PEDMKQDRDI QAVATSLLPL TEANLRMFQR AQDD
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (PubMed:30682371). Regulates HIV1 GAG-POL expression by inhibiting -1PRF (PubMed:30682371). Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137, PubMed:27974568). Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA (PubMed:27974568). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Interferon-regulated antiviral protein; IRAV; Repressor of yield of Dengue virus; Repressor of yield of DENV protein; RyDEN; SFL; shiftless; Shiftless antiviral inhibitor of ribosomal frameshifting protein; unnamed protein product; UPF0515 protein C19orf66
Gene Aliases: C19orf66; FLJ11286; IRAV; RYDEN; SFL; SHFL
UniProt ID: (Human) Q9NUL5
Entrez Gene ID: (Human) 55337
regulation of translational termination
response to type I interferon
response to interferon-gamma
response to type III interferon
response to interferon-beta
negative regulation of viral genome replication
innate immune response
defense response to virus
viral translational frameshifting
negative regulation of translational frameshifting
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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