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Invitrogen
P2X7 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-59823
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human C12orf76. Recombinant protein control fragment (Product #RP-98949).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AEVKEEIVEK EMKKLVHSVF NMADYTFPLQ
Highest antigen sequence identity to the following orthologs: Mouse - 60%, Rat - 57%.
Target Information
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP agonist non-selective cationic pore-forming protein; ATP receptor; ligand gated ion channel; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7 receptor; P2X7; cervical cancer susceptibility protein; P2Z; P2Z receptor; purinergic receptor P2X, ligand gated ion channel, 7; purnergic receptor P2X 7; unnamed protein product
Gene Aliases: P2X7
UniProt ID: (Human) Q99572
Entrez Gene ID: (Human) 5027
lipopolysaccharide binding
purinergic nucleotide receptor activity
extracellular ATP-gated cation channel activity
receptor binding
ion channel activity
potassium channel activity
sodium channel activity
protein binding
ATP binding
channel activity
signaling receptor activity
identical protein binding
regulation of sodium ion transport
response to ischemia
ion transport
cell surface receptor signaling pathway
positive regulation of calcium ion transport into cytosol
positive regulation of gene expression
organophosphate ester transport
phospholipid scrambling
sensory perception of pain
calcium-mediated signaling
positive regulation of bone mineralization
bleb assembly
positive regulation of interleukin-1 beta production
response to ATP
positive regulation of ion transmembrane transport
purinergic nucleotide receptor signaling pathway
sodium ion transmembrane transport
negative regulation of MAPK cascade
negative regulation of bone resorption
negative regulation of cell volume
positive regulation of glycolytic process
pore complex assembly
regulation of transport
positive regulation of cellular component organization
positive regulation of cytoskeleton organization
membrane depolarization
excitatory postsynaptic potential
protein homotrimerization
calcium ion transmembrane transport
cellular response to ATP
potassium ion transmembrane transport
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
cation transmembrane transport
positive regulation of NLRP3 inflammasome complex assembly
positive regulation of bleb assembly
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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