Search
Invitrogen
MFSD2A Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-60242
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MFSD2A. Recombinant protein control fragment (Product #RP-99818).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IVGQADTPCF QDLNSSTVAS QSANHTHGTT SHRETQ
Highest antigen sequence identity to the following orthologs: Mouse - 56%, Rat - 58%.
Target Information
Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: HsMFSD2A; major facilitator superfamily domain containing 2A; Major facilitator superfamily domain-containing protein 2A; NLS1; sodium-dependent LPC symporter 1; Sodium-dependent lysophosphatidylcholine symporter 1; unnamed protein product; zgc:101615
Gene Aliases: HMFN0656; HsMFSD2A; MCPH15; MFSD2; MFSD2A; NEDMISBA; NLS1; PP9177; SLC59A1; UNQ300/PRO341
UniProt ID: (Human) Q8NA29
Entrez Gene ID: (Human) 84879
retinal pigment epithelium development
phosphatidylcholine biosynthetic process
lipid transport
brain development
photoreceptor cell morphogenesis
carbohydrate transport
cellular response to starvation
positive regulation of triglyceride biosynthetic process
fatty acid transport
long-chain fatty acid transport
hippocampus development
positive regulation of cell growth
negative regulation of fatty acid beta-oxidation
lipid translocation
very-low-density lipoprotein particle assembly
maintenance of blood-brain barrier
photoreceptor cell outer segment organization
regulation of multicellular organism growth
transcytosis
regulation of dendrite development
cognition
lysophospholipid transport
transmembrane transport
retina morphogenesis in camera-type eye
establishment of blood-brain barrier
motor behavior
energy homeostasis
lysophospholipid translocation
regulation of neuron projection arborization
transport across blood-brain barrier
regulation of phosphatidylcholine metabolic process
regulation of phosphatidylethanolamine metabolic process
regulation of phosphatidylserine metabolic process
lipid transport across blood brain barrier
embryonic brain development
establishment of blood-retinal barrier
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support