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Invitrogen
CLCN3 Polyclonal Antibody
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Product Details
PA5-60802
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CLCN3. Recombinant protein control fragment (Product #RP-100451).
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NSITSASSDE ELLDGAGVIM DFQTSEDDNL LDGDTAVGTH YTMTNGGSIN SSTHLLDLLD EP
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
Target Information
Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chloride channel 3; Chloride channel protein 3; chloride channel, voltage-sensitive 3; Chloride transporter ClC-3; CIC3; ClC-3; CLC3; CLCN 3; clcn3e; DKFZp564I0463; H(+)/Cl(-) exchange transporter 3; protein kinase C-regulated chloride channel; unnamed protein product
Gene Aliases: ClC-3; CLC3; CLCN3; NEDHYBA; NEDSBA
UniProt ID: (Human) P51790, (Rat) P51792, (Mouse) P51791
Entrez Gene ID: (Human) 1182, (Rat) 84360, (Mouse) 12725
nucleotide binding
voltage-gated chloride channel activity
chloride channel activity
protein binding
ATP binding
chloride transmembrane transporter activity
antiporter activity
PDZ domain binding
chloride:proton antiporter activity
volume-sensitive chloride channel activity
ion channel activity
voltage-gated ion channel activity
protein heterodimerization activity
ion channel
ion transport
chloride transport
regulation of pH
phagocytosis, engulfment
adult locomotory behavior
synaptic transmission, glutamatergic
photoreceptor cell maintenance
negative regulation of cell volume
endosomal lumen acidification
synaptic transmission, GABAergic
transmembrane transport
neuron cellular homeostasis
synaptic vesicle lumen acidification
chloride transmembrane transport
positive regulation of reactive oxygen species biosynthetic process
ion transmembrane transport
regulation of ion transmembrane transport
regulation of anion transport
transport
regulation of anion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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