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Invitrogen

Nhe-1 Polyclonal Antibody

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Nhe-1 Polyclonal Antibody

Product Details

PA5-61764

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Nhe-1. Recombinant protein control fragment (Product #RP-103029).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

10 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2644660

Product Specific Information

Immunogen sequence: KILRNNLQKT RQRLRSYNRH TLVADPYEEA WNQMLLRRQK ARQLEQKINN YLTVPAHKLD SPTMSRARIG SDPLAYEPKE DLPVITIDPA

Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 97%.

Target Information

The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: APNH; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1; Na-Li countertransporter; NHE-1; plasma membrane antiporter; hemopoietic NHE1; APNH; protein phosphatase 1, regulatory subunit 143; Sodium/hydrogen exchanger 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); Solute carrier family 9 member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; unnamed protein product

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Gene Aliases: APNH; APNH1; LIKNS; NHE-1; NHE1; PPP1R143; SLC9A1

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UniProt ID: (Human) P19634

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Entrez Gene ID: (Human) 6548

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Function(s)
protein binding calmodulin binding phospholipid binding phosphatidylinositol-4,5-bisphosphate binding antiporter activity sodium:proton antiporter activity potassium:proton antiporter activity protein phosphatase 2B binding protein binding, bridging identical protein binding calcium-dependent protein binding binding, bridging
Process(es)
regulation of the force of heart contraction ion transport cation transport sodium ion transport cellular sodium ion homeostasis regulation of pH response to acidic pH positive regulation of cardiac muscle hypertrophy regulation of cardiac muscle contraction by calcium ion signaling cell migration maintenance of cell polarity cell differentiation positive regulation of cell growth cellular response to insulin stimulus positive regulation of mitochondrial membrane permeability response to muscle stretch sodium ion export from cell positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of action potential positive regulation of transcription from RNA polymerase II promoter stem cell differentiation protein oligomerization regulation of intracellular pH regulation of stress fiber assembly regulation of focal adhesion assembly cardiac muscle cell differentiation transmembrane transport cellular response to cold positive regulation of calcineurin-NFAT signaling cascade cellular response to antibiotic cellular response to electrical stimulus cellular response to mechanical stimulus cellular response to hypoxia cellular response to acidic pH potassium ion transmembrane transport cellular response to epinephrine stimulus cardiac muscle cell contraction regulation of cardiac muscle cell membrane potential regulation of the force of heart contraction by cardiac conduction sodium ion import across plasma membrane positive regulation of the force of heart contraction positive regulation of intracellular signal transduction hydrogen ion transmembrane transport
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