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Invitrogen
TRIM32 Polyclonal Antibody
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Product Details
PA5-62127
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TRIM32. Recombinant protein control fragment (Product #RP-101224).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NLTPLSVAMN CQGLIGVTDS YDNSLKVYTL DGHCVACHRS QLSKPWGITA LPSGQFVVTD VEGGKLWCFT VDRGSGVVKY SCLCSAVRPK FVTCDA
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 98%.
Target Information
TRIM32 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM32 localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 72 kDa Tat-interacting protein; E3 ubiquitin-protein ligase TRIM32; RING-type E3 ubiquitin transferase TRIM32; RP11-67K19.1; TAT-interactive protein, 72-KD; tripartite motif-containing 32; Tripartite motif-containing protein 32; Zinc finger protein HT2A; zinc-finger protein HT2A
Gene Aliases: BBS11; HT2A; LGMD2H; TATIP; TRIM32
UniProt ID: (Human) Q13049
Entrez Gene ID: (Human) 22954
protein polyubiquitination
tissue homeostasis
actin ubiquitination
response to UV
protein ubiquitination
positive regulation of cell growth
positive regulation of cell migration
regulation of type I interferon production
negative regulation of viral transcription
response to tumor necrosis factor
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
fat cell differentiation
positive regulation of neuron differentiation
positive regulation of protein catabolic process
positive regulation of cell cycle
positive regulation of proteolysis
muscle cell cellular homeostasis
negative regulation of fibroblast proliferation
positive regulation of neurogenesis
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of striated muscle cell differentiation
axon development
negative regulation of viral release from host cell
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of interleukin-17-mediated signaling pathway
positive regulation of chemokine (C-C motif) ligand 20 production
positive regulation of cell motility
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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