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Invitrogen
XPG Polyclonal Antibody
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Product Details
PA5-62177
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human XPG. Recombinant protein control fragment (Product #RP-95291).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EKEFELLDKA KRKTQKRGIT NTLEESSSLK RKRLSDSKRK NTCGGFLGET CLSESSDGSS SEDAESSSLM NVQRRTAAKE PKTSASDSQN SVKEAPVK
Highest antigen sequence identity to the following orthologs: Mouse - 43%, Rat - 44%.
Target Information
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: COFS 3; DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; ERCC 5; ERCC5; ERCC5-201; ERCM 2; excision repair cross-complementation group 5; excision repair cross-complementing rodent repair deficiency, complementation group 5; OTTHUMP00000064902; RP11-484I6.5; unnamed protein product; Xe; xeroderma pigmentosum; Xeroderma pigmentosum group G-complementing protein; xeroderma pigmentosum, complementation group G; XPG; XPG-complementing protein
Gene Aliases: COFS3; ERCC5; ERCC5-201; ERCM2; UVDR; XPG; XPGC
UniProt ID: (Human) P28715
Entrez Gene ID: (Human) 2073
bubble DNA binding
RNA polymerase II core binding
DNA binding
damaged DNA binding
double-stranded DNA binding
single-stranded DNA binding
catalytic activity
nuclease activity
endonuclease activity
endodeoxyribonuclease activity
protein binding
enzyme activator activity
hydrolase activity
hydrolase activity, acting on ester bonds
protein homodimerization activity
macromolecular complex binding
metal ion binding
double-strand break repair via homologous recombination
DNA repair
transcription-coupled nucleotide-excision repair
base-excision repair, AP site formation
nucleotide-excision repair
DNA recombination
cellular response to DNA damage stimulus
response to UV
response to UV-C
negative regulation of apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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