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Invitrogen
DPM1 Polyclonal Antibody
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Product Details
PA5-62490
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DPM1. Recombinant protein control fragment (Product #RP-99290).
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SLEVSRSPRR SRRELEVRSP RQNKYSVLLP TYNERENLPL IVWLLVKSFS ESGINYEIII IDDGSPDGTR DVAEQLEKIY GSD
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 81%.
Target Information
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dolichol monophosphate mannose synthase; Dolichol-phosphate mannose synthase subunit 1; Dolichol-phosphate mannosyltransferase subunit 1; Dolichyl-phosphate beta-D-mannosyltransferase subunit 1; dolichyl-phosphate mannosyltransferase polypeptide 1 catalytic subunit; DPM synthase complex, catalytic subunit; DPM synthase subunit 1; DPM1; Mannose-P-dolichol synthase subunit 1; MPD synthase subunit 1; OTTMUSP00000017164; RP23-391M18.1; unnamed protein product
Gene Aliases: CDGIE; DPM1; MPDS
UniProt ID: (Human) O60762
Entrez Gene ID: (Human) 8813
protein glycosylation
dolichol-linked oligosaccharide biosynthetic process
GPI anchor biosynthetic process
protein N-linked glycosylation via asparagine
dolichol metabolic process
GDP-mannose metabolic process
protein mannosylation
protein O-linked mannosylation
response to oxygen levels
dolichol phosphate mannose biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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