Immunofluorecent analysis of DAB1 in human cell line RT4 using DAB1 Polyclonal Antibody (Product # PA5-62538). Staining shows localization to vesicles.

DAB1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

DAB1 Antibody in Immunohistochemistry (IHC)

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DAB1 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of DAB1 demonstrates antibody specificity. Immunohistochemical analysis of DAB1 using anti-DAB1 Polyclonal Antibody (Product # PA5-62538), shows significant staining of DAB1 in human small intestine and shows minimal or weak staining in human liver tissues. The relative expression levels of DAB1 within each tissue is shown using RNA-Seq. {RE}

Immunogen image

Immunogen Image DAB1 Polyclonal Antibody

Product Details

PA5-62538

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human DAB1. Recombinant protein control fragment (Product #RP-103113).

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2640363

Product Specific Information

Immunogen sequence: TPAPRQSSPS KSSASHASDP TTDDIFEEGF ESPSKSEEQE APDGSQASSN SDPFGEPSGE PSGDNISPQ

Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

Target Information

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Dab reelin signal transducer 1; Dab, reelin signal transducer, homolog 1; DAB1, reelin adaptor protein; Disabled homolog 1; mDab1; RP23-356E21.1; spinocerebellar ataxia 37; unnamed protein product; yotari

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Gene Aliases: AI956902; C630028C02Rik; DAB1; SCA37; scm; scr; scrambler; yot

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UniProt ID: (Human) O75553, (Mouse) P97318

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Entrez Gene ID: (Human) 1600, (Mouse) 13131

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Function(s)

protein binding signaling adaptor activity phospholipid binding SH2 domain binding phosphatidylinositol 3-kinase binding scaffold/adaptor protein

Process(es)

neuron migration cell adhesion negative regulation of cell adhesion JAK-STAT cascade small GTPase mediated signal transduction nervous system development axonogenesis adult walking behavior dendrite development ventral spinal cord development cerebellum structural organization hippocampus development cerebral cortex cell migration cerebral cortex radially oriented cell migration cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration layer formation in cerebral cortex radial glia guided migration of Purkinje cell central nervous system neuron differentiation cell differentiation neuron differentiation reelin-mediated signaling pathway positive regulation of neuron differentiation negative regulation of JAK-STAT cascade astrocyte differentiation negative regulation of astrocyte differentiation negative regulation of axonogenesis Golgi localization regulation of synapse maturation motor neuron migration lateral motor column neuron migration radial glia-guided pyramidal neuron migration multicellular organism development central nervous system development intracellular signal transduction positive regulation of protein kinase activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DAB1 Polyclonal Antibody

DAB1 Antibody (PA5-62538) in ICC/IF

Product Details

PA5-62538

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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