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Invitrogen
TRIAP1 Polyclonal Antibody
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Product Details
PA5-62821
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TRIAP1. Recombinant protein control fragment (Product #RP-92082).
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EACTDMKREY DQCFNRWFAE KFLKGDSSGD PCTDLFKRYQ QCVQKAIKEK EIPIEGLEFM GHGKE
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mitochondrial distribution and morphology 35 homolog; p53-inducible cell-survival factor; p53CSV; Protein 15E1.1; TP53-regulated inhibitor of apoptosis 1; unnamed protein product; WF-1
Gene Aliases: 15E1.1; HSPC132; MDM35; P53CSV; TRIAP1; WF-1
UniProt ID: (Human) O43715
Entrez Gene ID: (Human) 51499
lipid transport
apoptotic process
phospholipid transport
DNA damage response, signal transduction by p53 class mediator
mitotic G1 DNA damage checkpoint
cellular response to UV
negative regulation of apoptotic process
phospholipid translocation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of release of cytochrome c from mitochondria
regulation of membrane lipid distribution
intermembrane lipid transfer
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of phospholipid transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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