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Invitrogen
RCAN2 Polyclonal Antibody
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Product Details
PA5-62860
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RCAN2. Recombinant protein control fragment (Product #RP-101503).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PSMDCDVSTL VACVVDVEVF TNQEVKE
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcipressin-2; Down syndrome candidate region 1-like 1; Down syndrome critical region gene 1-like 1; MCIP2; Myocyte-enriched calcineurin-interacting protein 2; Regulator of calcineurin 2; thyroid hormone-responsive (skin fibroblasts); Thyroid hormone-responsive protein ZAKI-4
Gene Aliases: CSP2; DSCR1L1; MCIP2; RCAN2; RCN2; ZAKI-4; ZAKI4
UniProt ID: (Human) Q14206
Entrez Gene ID: (Human) 10231
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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