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Invitrogen
Spectrin beta-4 Polyclonal Antibody
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Product Details
PA5-62972
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Spectrin beta-4. Recombinant protein control fragment (Product #RP-104041).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AWEERFSSLR RLTTIEKIKA EQSKQPPTPL LGRKFFGDPT ELAAKAAPLL RPGGYERGLE PLARRASDTL SAEVRTRVGY VRQELKPERL QPRIDRLP
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
Spectrin is the major constituent of the cytoskeletal network underlying the erthrocyte plasma membrane and determines cell shape, arrangement of transmembrane proteins and organization of organelles. It is expressed at very low levels in many tissues, with the strongest expression in the cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder and heart. Spectrin beta 4 is a non-erythrocyte member, and is expressed in the brain and pancreatic islets and localisted to the nuclear matrix, cytoplasmic vesicles and PML nuclear bodies. Beta4 spectrins are also essential for membrane stability and the molecular organization of the nodes of Ranvier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 289 kDa isoform; 77 kDa isoform; beta SpIV; Beta-IV spectrin; cytoskeletal protein; alternatively spliced; EMBL BAB83243.1; spectrin beta chain, brain 3; Spectrin beta chain, non-erythrocytic 4; Spectrin, non-erythroid beta chain 3; SPNB4
Gene Aliases: CMND; KIAA1642; NEDHND; QV; SPNB4; SPTBN3; SPTBN4
UniProt ID: (Human) Q9H254
Entrez Gene ID: (Human) 57731
regulation of sodium ion transport
axonogenesis
neuromuscular junction development
sensory perception of sound
adult walking behavior
protein localization
fertilization
negative regulation of heart rate
vesicle-mediated transport
transmission of nerve impulse
central nervous system projection neuron axonogenesis
actin cytoskeleton organization
adult behavior
positive regulation of multicellular organism growth
clustering of voltage-gated sodium channels
neuromuscular process
actin filament capping
cardiac conduction
protein-containing complex assembly
protein localization to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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