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Invitrogen
SAM68 Polyclonal Antibody
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FIGURE: 1 / 10
SAM68 Antibody (PA5-63349) in ICC/IF
Immunofluorescence analysis of SAM68 was performed using MCF7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with SAM68 Polyclonal Antibody (Product # PA5-63349) at 2 µg/mL in 0.1% BSA and incubated overnight at 4 degree and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034) at a dilution of 1:2000 for 45 mi... View More
Product Details
PA5-63349
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SAM68. Recombinant protein control fragment (Product #RP-103271).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ALVRGTPVRG AITRGATVTR GVPPPPTVRG APAPRARTAG IQRIPLP
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Target Information
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ34027; GAP-associated tyrosine phosphoprotein p62; GAP-associated tyrosine phosphoprotein p62 (Sam68); KH domain containing, RNA binding, signal transduction associated 1; KH domain-containing, RNA-binding, signal transduction-associated protein 1; p21 Ras GTPase-activating protein-associated p62; p68; Sam68; Src-associated in mitosis 68 kDa protein; unnamed protein product
Gene Aliases: KHDRBS1; p62; p68; SAM68
UniProt ID: (Human) Q07666
Entrez Gene ID: (Human) 10657
nucleic acid binding
DNA binding
RNA binding
mRNA binding
protein binding
poly(A) binding
poly(U) RNA binding
SH3 domain binding
protein domain specific binding
signaling adaptor activity
SH2 domain binding
identical protein binding
macromolecular complex binding
molecular function inhibitor activity
protein tyrosine kinase binding
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
regulation of alternative mRNA splicing, via spliceosome
mRNA processing
cell surface receptor signaling pathway
spermatogenesis
regulation of protein stability
regulation of apoptotic process
regulation of RNA splicing
negative regulation of transcription, DNA-templated
positive regulation of translational initiation
regulation of RNA export from nucleus
positive regulation of RNA export from nucleus
regulation of mRNA splicing, via spliceosome
T cell receptor signaling pathway
regulation of cell cycle
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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