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Invitrogen
MIA3 Polyclonal Antibody
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Product Details
PA5-63351
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MIA3. Recombinant protein control fragment (Product #RP-99800).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LGMNENNIFE EAAVLDDIQD LIYFVRYKHS TAEETATLVM APPLEEGLGG AMEEMQPLHE DNFSREKTAE LNVQVPEEPT HLDQRVI
Highest antigen sequence identity to the following orthologs: Mouse - 25%, Rat - 54%.
Target Information
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C219-reactive peptide; D320; KIAA0268; melanoma inhibitory activity family, member 3; Melanoma inhibitory activity protein 3; MIA family member 3, ER export factor; RP11-378J18.4; secreted protein; TANGO1; Transport and Golgi organization protein 1 homolog; unnamed protein product
Gene Aliases: ARNT; D320; KIAA0268; MIA3; ODCD2; TANGO; TANGO1; UNQ6077; UNQ6077/PRO20088
UniProt ID: (Human) Q5JRA6
Entrez Gene ID: (Human) 375056
cell migration involved in sprouting angiogenesis
positive regulation of leukocyte migration
exocytosis
ER to Golgi vesicle-mediated transport
endoplasmic reticulum organization
negative regulation of cell adhesion
protein secretion
protein transport
vesicle-mediated transport
negative regulation of cell migration
cargo loading into vesicle
wound healing
lipoprotein transport
system development
protein localization to endoplasmic reticulum exit site
cargo loading into COPII-coated vesicle
cellular response to oxidised low-density lipoprotein particle stimulus
negative regulation of leukocyte cell-cell adhesion
negative regulation of lymphocyte migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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