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Invitrogen

SUV39H2 Polyclonal Antibody

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View all (13) SUV39H2 antibodies

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SUV39H2 Polyclonal Antibody

Product Details

PA5-63450

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SUV39H2. Recombinant protein control fragment (Product #RP-103302).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2648099

Product Specific Information

Immunogen sequence: NTVDLEGPPS DFYYINEYKP APGISLVNEA TFGCSCTDCF FQKCCPAEAG VLLAYNKNQQ IKIPPGTPI

Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 87%.

Target Information

The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ23414; H3 K9 HMTase 2; H3-K9-HMTase 2; Histone H3-K9 methyltransferase 2; histone methyltransferase SUV39H2; Histone-lysine N-methyltransferase SUV39H2; KMT1; Lysine N-methyltransferase 1B; RP11-2K17.2; Su; Su(var)3-9 homolog 2; Suppressor of variegation 3-9 homolog 2; SUV39H2; unnamed protein product

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Gene Aliases: KMT1B; SUV39H2

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UniProt ID: (Human) Q9H5I1

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Entrez Gene ID: (Human) 79723

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