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Invitrogen
SUV39H2 Polyclonal Antibody
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Product Details
PA5-63450
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SUV39H2. Recombinant protein control fragment (Product #RP-103302).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NTVDLEGPPS DFYYINEYKP APGISLVNEA TFGCSCTDCF FQKCCPAEAG VLLAYNKNQQ IKIPPGTPI
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 87%.
Target Information
The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ23414; H3 K9 HMTase 2; H3-K9-HMTase 2; Histone H3-K9 methyltransferase 2; histone methyltransferase SUV39H2; Histone-lysine N-methyltransferase SUV39H2; KMT1; Lysine N-methyltransferase 1B; RP11-2K17.2; Su; Su(var)3-9 homolog 2; Suppressor of variegation 3-9 homolog 2; SUV39H2; unnamed protein product
Gene Aliases: KMT1B; SUV39H2
UniProt ID: (Human) Q9H5I1
Entrez Gene ID: (Human) 79723
transcription regulatory region sequence-specific DNA binding
protein binding
methyltransferase activity
zinc ion binding
transferase activity
histone methyltransferase activity
metal ion binding
histone methyltransferase activity (H3-K9 specific)
histone H3 methyltransferase activity
histone H3K9 trimethyltransferase activity
S-adenosyl-L-methionine binding
protein binding, bridging involved in substrate recognition for ubiquitination
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
chromatin remodeling
circadian rhythm
cell differentiation
methylation
epigenetic programming in the zygotic pronuclei
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
rhythmic process
cellular response to hypoxia
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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