Invitrogen

Lymphotactin Polyclonal Antibody

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Datasheet
Protocols
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Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support
Lymphotactin Polyclonal Antibody

Product Details

PA5-63473

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Lymphotactin. Recombinant protein control fragment (Product #RP-104515).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2643623

Product Specific Information

Immunogen sequence: VCADPQATWV RDVVRSMDRK SNTRNNMIQT KPTGTQQSTN TAVTLTG

Highest antigen sequence identity to the following orthologs: Mouse - 53%, Rat - 40%.

Target Information

Lymphotactin, otherwise known as XCL1, is a member of the C-chemokine family that uniquely acts as a chemoattractant for lymphocytes, but not monocytes or neutrophils, suggesting an important regulatory role in lymphocyte trafficking and inflammation. Lymphotactin, shown to signal through chemokine XC receptor 1 (XCR1), is detected at the highest level in the spleen and at low levels in the lungs, small intestine and colon, and is abundantly and selectively expressed by activated T cells, in particular CD8+ T cells, and is also produced by NK cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATAC; C motif chemokine 1; chemokine (C motif) ligand 1; Cytokine SCM-1; Lymphotactin; Lymphotaxin; SCM-1-alpha; SCM-1-beta; SCM-1alpha; SCM-1beta; SCM1alpha; SCM1beta; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); Small-inducible cytokine C1; XC chemokine ligand 1

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Gene Aliases: ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1; SCM1A; SCYC1; XCL1

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UniProt ID: (Human) P47992

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Entrez Gene ID: (Human) 6375

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Function(s)
chemokine activity chemokine receptor binding protein homodimerization activity CCR chemokine receptor binding cytokine intercellular signal molecule
Process(es)
positive regulation of T cell mediated cytotoxicity monocyte chemotaxis positive regulation of leukocyte chemotaxis negative regulation of T cell cytokine production positive regulation of T cell cytokine production negative regulation of T-helper 1 type immune response signal transduction G-protein coupled receptor signaling pathway cell-cell signaling response to virus positive regulation of T cell chemotaxis neutrophil chemotaxis negative regulation of interferon-gamma production negative regulation of interleukin-2 production positive regulation of interleukin-10 production mature natural killer cell chemotaxis negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of GTPase activity negative regulation of transcription, DNA-templated regulation of inflammatory response positive regulation of inflammatory response release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-4 cellular response to tumor necrosis factor cellular response to transforming growth factor beta stimulus positive regulation of transforming growth factor beta production positive regulation of granzyme B production positive regulation of neutrophil chemotaxis positive regulation of thymocyte migration positive regulation of natural killer cell chemotaxis positive regulation of granzyme A production negative regulation of T-helper 1 cell activation positive regulation of B cell chemotaxis positive regulation of T-helper 2 cell cytokine production positive regulation of T-helper 1 cell cytokine production positive regulation of immunoglobulin production in mucosal tissue negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of CD8-positive, alpha-beta T cell proliferation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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