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Invitrogen
Ubiquilin 4 Polyclonal Antibody
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Product Details
PA5-63986
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Ubiquilin 4. Recombinant protein control fragment (Product #RP-104299).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EGTGGSGTSQ VHPTVSNPFG INAASLGSGM FNSPEMQALL QQISEN
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A1Up; Ataxin-1 interacting ubiquitin-like protein; ataxin-1 ubiquitin-like interacting protein; Ataxin-1 ubiquitin-like-interacting protein A1U; CIP75; Connexin43-interacting protein of 75 kDa; Cx43-interacting protein of 75 kDa; RP11-336K24.8; Ubiquilin-4; unnamed protein product
Gene Aliases: A1U; A1Up; C1orf6; CIP75; UBIN; UBQLN4
UniProt ID: (Human) Q9NRR5
Entrez Gene ID: (Human) 56893
DNA repair
ubiquitin-dependent protein catabolic process
autophagy
cellular response to DNA damage stimulus
regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to stress
regulation of proteasomal protein catabolic process
regulation of cellular response to stress
negative regulation of autophagosome maturation
negative regulation of double-strand break repair via homologous recombination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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