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Invitrogen
TMEM108 Polyclonal Antibody
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Product Details
PA5-64110
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TMEM108. Recombinant protein control fragment (Product #RP-103506).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EPEPSTLTPR TPLWGYSSSP QPQTVAATTV PSNTSWAPTT TSLGPAKDKP GLRRAAQGGG STFTSQGGTP DATAASGAPV SPQAAPVP
Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 67%.
Target Information
Transmembrane protein 108 (TMEM108) is a gene associated with psychiatric disorders such as schizophrenia, bipolar disorder, and major depression disorder. It is specifically expressed in the nervous system, particularly enriched in the postsynaptic density fraction and DG granule neurons. Research has shown that TMEM108 is critical for adult neurogenesis in the hippocampal dentate gyrus, indicating its role in neuronal development and function. Studies with TMEM108 mutant mice exhibit mania-like behavior, highlighting its involvement in the pathology of bipolar disorder. The gene's expression is notably higher in oligodendrocyte lineage cells within the central nervous system compared to other lineage cells. As a schizophrenia susceptibility gene, TMEM108 has been identified as a potential target for understanding the underlying mechanisms of psychiatric diseases and for developing therapeutic approaches. However, the detailed pathophysiological mechanisms by which TMEM108 contributes to such disorders remain largely unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cancer/testis antigen 124; Retrolinkin; Transmembrane protein 108; unnamed protein product
Gene Aliases: CT124; KIAA1690; RTLN; TMEM108; UNQ1875/PRO4318
UniProt ID: (Human) Q6UXF1
Entrez Gene ID: (Human) 66000
receptor-mediated endocytosis
retrograde axonal transport
dentate gyrus development
neuron projection development
positive regulation of neurotrophin TRK receptor signaling pathway
postsynaptic density organization
dendrite extension
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
modulation of excitatory postsynaptic potential
cellular response to brain-derived neurotrophic factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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