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Invitrogen
AMER1 Polyclonal Antibody
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Product Details
PA5-64204
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human AMER1. Recombinant protein control fragment (Product #RP-104159).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RDSPLSLYTE PPGAYDWPAW APCPLPVGPG PAWISPNQLD RPSSQSPYRQ ATCCIPPMTM SISLSVPESR APGESGPQLA RPSHLHLP
Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 69%.
Target Information
The AMER1 gene encodes the protein APC membrane recruitment 1, also known as Wilms tumor 1-associating protein (WT1-associating protein). This protein plays a significant role in the Wnt signaling pathway, which is critical for cellular processes such as proliferation, differentiation, and migration. AMER1 interacts with the adenomatous polyposis coli (APC) protein and is involved in the regulation of β-catenin, a key mediator of Wnt signaling. By recruiting APC to the cell membrane, AMER1 facilitates the degradation of β-catenin, thereby acting as a negative regulator of the pathway. This function is vital in maintaining cellular homeostasis and preventing uncontrolled cell growth. Mutations or dysregulation of AMER1 are associated with various cancers, including colorectal cancer, as aberrant Wnt signaling can lead to oncogenesis. Moreover, germline mutations in AMER1 are linked to conditions such as osteoporosis-pseudoglioma syndrome, highlighting its role in bone development and eye health. Ongoing research focuses on elucidating the detailed mechanisms of AMER1's involvement in signaling pathways and its potential as a therapeutic target in cancer and genetic disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adenomatous polyposis coli membrane recruitment 1; Amer1; APC membrane recruitment protein 1; family with sequence similarity 123B; Protein FAM123B; RP11-403E24.2; Wilms tumor gene on the X chromosome protein; Wilms tumor on the X
Gene Aliases: AMER1; FAM123B; OSCS; WTX
UniProt ID: (Human) Q5JTC6
Entrez Gene ID: (Human) 139285
Wnt signaling pathway
positive regulation of protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
anatomical structure development
bone development
adipose tissue development
regulation of canonical Wnt signaling pathway
mesenchymal cell differentiation involved in kidney development
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of cellular protein catabolic process
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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