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Invitrogen
Aquaporin 0 Polyclonal Antibody
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Product Details
PA5-64958
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Aquaporin 0. Recombinant protein control fragment (Product #RP-105733).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RLKSISERLSV LKGAKPDVSN GQPEVTGEPV ELNTQAL
Highest antigen sequence identity to the following orthologs - mouse 82%, rat 82%.
Target Information
AQP0 is the most abundant endogenous protein in the plasma membrane of lens fiber cells where it functions not only as a water pore, but it is also involved in fiber-fiber adhesion and is crucial for fiber cell structure and organization. AQP0 contains an additional pore constriction, not seen in any other aquaporin structures, which may be responsible for pore gating. The closed AQP0 pore holds just three water molecules, which are spaced too far apart to form hydrogen bonds with each other. The C-terminal domain of AQP0 undergoes extensive post-translational modification, including many truncations, during lens aging due to the actions of m-calpain, proteases or non-enzymatic mechanisms. These truncation sites may be involved in the development of cataracts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aquaporin 0; Aquaporin-0; Aquaporin0; Lens fiber major intrinsic protein; MIP26; MP26
Gene Aliases: AQP0; CTRCT15; LIM1; MIP; MIP26; MP26
UniProt ID: (Human) P30301
Entrez Gene ID: (Human) 4284
lens development in camera-type eye
water transport
visual perception
cellular water homeostasis
canalicular bile acid transport
glycerol transport
ion transmembrane transport
positive regulation of cell adhesion
response to stimulus
protein homotetramerization
gap junction-mediated intercellular transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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