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Invitrogen
MCM8 Polyclonal Antibody
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Product Details
PA5-65399
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Fruit fly
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human MCM8. Recombinant protein control fragment (Product #RP-104804).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ERKGSILVDFK ELTEGGEVTN LIPDIATELR DAPEKTLACM GLAIHQVLTK DLERHAAELQ AQEGLSNDGE TMVNVPHIHA RVYNYEPLTQ LKNVRANYYG KYIALRGTVV RVSNIKPLCT KMAFLCAACG EIQSFPLPDG KYSL
Highest antigen sequence identity to the following orthologs - mouse 88%, rat 87%.
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA 3'-5' helicase MCM8; DNA helicase MCM8; DNA replication licensing factor MCM8; MCM8 minichromosome maintenance deficient 8; MGC119522; MGC119523; MGC12866; MGC4816; Minichromosome maintenance 8; minichromosome maintenance complex component 8; REC; REC homolog; unnamed protein product
Gene Aliases: C20orf154; dJ967N21.5; MCM8; POF10
UniProt ID: (Human) Q9UJA3
Entrez Gene ID: (Human) 84515
nucleotide binding
DNA binding
chromatin binding
single-stranded DNA binding
helicase activity
protein binding
ATP binding
hydrolase activity
ATPase activity
single-stranded DNA-dependent ATP-dependent DNA helicase activity
enzyme binding
MutLbeta complex binding
MutSalpha complex binding
MutSbeta complex binding
double-strand break repair via homologous recombination
DNA replication
DNA repair
cellular response to DNA damage stimulus
female gamete generation
recombinational interstrand cross-link repair
male gamete generation
protein stabilization
mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
protein localization to chromatin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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