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Invitrogen
IFI35 Polyclonal Antibody
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Product Details
PA5-65421
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human IFI35. Recombinant protein control fragment (Product #RP-106104).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VDVRELLPGSV MLGFARDGVA QRLCQIGQFT VPLGGQQVPL RVSPYVNGEI QKAEIRSQPV PRSVLVLNIP DILDGPELHD VLEIHFQKPT RGGGEVEALT VVPQGQQGLA VFTSESG
Highest antigen sequence identity to the following orthologs - mouse 76%, rat 77%.
Target Information
Interferon-Induced Protein 35 (IFI35), encoded by the IFI35 gene, is located on chromosome 17 and is recognized for its role in immune response modulation, especially under viral stress conditions. Structurally, IFI35 is part of a complex regulatory network that influences non-canonical NF-kB signaling. This process involves the proteasomal processing of p105 into the DNA-binding transcription factor p50, which forms a heterodimer with RELB (RELB/p50) to activate cell chemotaxis autonomously. The gene's dynamic expression under viral stress has been linked to various immune regulatory networks and is crucial for immune cell recruitment and maintenance, particularly M2-like tumor-associated macrophages (TAMs) within the tumor microenvironment. IFI35 upregulation is significant in conditions of neuroinflammation and multiple sclerosis, especially in patients treated with interferons (IFN), indicating its potential as a biomolecular marker. Additionally, IFI35's role in triple-negative breast cancer highlights its impact on antitumor immunity, where its ablation enhances the infiltration of effector CD8+ T cells and sensitizes tumors to anti-PD-1 immunotherapy. This positions IFI35 as a key player in both immune response and cancer treatment strategies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ifi-35; IFP 35; Interferon-induced 35 kDa protein
Gene Aliases: IFI35; IFP35
UniProt ID: (Human) P80217
Entrez Gene ID: (Human) 3430
macrophage activation involved in immune response
immune system process
negative regulation of cell proliferation
positive regulation of toll-like receptor 4 signaling pathway
innate immune response
regulation of innate immune response
positive regulation of innate immune response
positive regulation of inflammatory response
negative regulation of NIK/NF-kappaB signaling
positive regulation of NIK/NF-kappaB signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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