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Invitrogen
XPB Polyclonal Antibody
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Product Details
PA5-65423
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human XPB. Recombinant protein control fragment (Product #RP-106107).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KLCTVSYGKVK LVLKHNRYFV ESCHPDVIQH LLQDPVIREC RLRNSEGEAT ELITETFTSK SAISKTAESS GGPSTSRVTD PQGKSDIPMD LFDFYEQMDK DEEEEE
Highest antigen sequence identity to the following orthologs - mouse 90%, rat 90%.
Target Information
The human XPB DNA helicase is a subunit of the DNA repair/basal transcription factor TFIIH, and is involved in early steps of the nucleotide excision repair (NER) pathway. Two distinct clinical phenotypes, xeroderma pigmentosum associated with Cockayne's syndrome (XP/CS) and trichothiodystrophy (TTD), can be due to mutations in the XPB gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Basic transcription factor 2 89 kDa subunit; BTF2 p89; DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; DNA repair helicase; DNA repair protein complementing XP-B cells; excision repair cross-complementation group 3; excision repair cross-complementing rodent repair deficiency, complementation group 3; general transcription and DNA repair factor IIH helicase subunit XPB; General transcription and DNA repair factor IIH helicase/translocase subunit XPB; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH p89; TFIIH subunit XPB; unnamed protein product; Xeroderma pigmentosum group B-complementing protein; xeroderma pigmentosum, complementation group B
Gene Aliases: BTF2; ERCC3; GTF2H; RAD25; Ssl2; TFIIH; TTD2; XPB; XPBC
UniProt ID: (Human) P19447
Entrez Gene ID: (Human) 2071
DNA topological change
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
protein localization
response to UV
UV protection
hair cell differentiation
positive regulation of apoptotic process
embryonic organ development
regulation of mitotic cell cycle phase transition
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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