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Invitrogen
Casc5 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-65573
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Casc5. Recombinant protein control fragment (Product #RP-106240).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DVTKQVIQTHV NAGEAPDPVI TSNVPCFHSI KPNLNNLNGK TGEFLAFQTV HLPPLPEQLL ELGNKAHNDM HIVQATEIHN INIISSNAKD SRDEENKKSH NGAETTSLPP KTVFKDKVRR CSLGIFLPRL PNKRNCSVTG IDDLEQ
Highest antigen sequence identity to the following orthologs - mouse 60%, rat 60%.
Target Information
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALL1-fused gene from chromosome 15q14 protein; blinkin, bub-linking kinetochore protein; cancer susceptibility candidate 5; cancer susceptibility candidate gene 5 protein; cancer/testis antigen 29; D40; kinetochore null 1 homolog; kinetochore-null protein 1; microcephaly, primary autosomal recessive 4; protein phosphatase 1, regulatory subunit 55
Gene Aliases: AF15Q14; CASC5; CT29; D40; hKNL-1; hSpc105; MCPH4; PPP1R55; Spc7
UniProt ID: (Human) Q8NG31
Entrez Gene ID: (Human) 57082
mitotic sister chromatid segregation
acrosome assembly
attachment of spindle microtubules to kinetochore
protein localization to kinetochore
cell division
attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation
regulation of mitotic cell cycle spindle assembly checkpoint
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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