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Invitrogen
53BP2 Polyclonal Antibody
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Product Details
PA5-65618
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human 53BP2. Recombinant protein control fragment (Product #RP-104898).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TISVPSYPSKS ASVTASSESP VEIQNPYLHV EPEKEVVSLV PESLSPEDVG NASTENSDMP APSPGLDYEP EGVPDNSPNL QNNPEEPNPE APHVLDVYLE
Highest antigen sequence identity to the following orthologs - mouse 76%, rat 75%.
Target Information
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 53BP2; Apoptosis-stimulating of p53 protein 2; apoptosis-stimulating protein of p53, 2; Bbp; BCL2-binding protein; P PPP1R13A; Renal carcinoma antigen NY-REN-51; tumor protein p53 binding protein, 2; Tumor suppressor p53-binding protein 2
Gene Aliases: 53BP2; ASPP2; BBP; P53BP2; PPP1R13A; TP53BP2
UniProt ID: (Human) Q13625
Entrez Gene ID: (Human) 7159
cell cycle
signal transduction
regulation of apoptotic process
negative regulation of cell cycle
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of execution phase of apoptosis
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of neuron death
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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