Search
Invitrogen
Histone Macro-H2A.1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-65647
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human H2AFY. Recombinant protein control fragment (Product #RP-104915).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GKLEAIITPPP AKKAKSPSQK KPVSKKAGGK KGARKSKKKQ GEVSKAASAD STTEGTPADG FTVLSTK
Highest antigen sequence identity to the following orthologs - mouse 96%, rat 93%.
Target Information
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: H2A histone family member Y; histone H2A.y; histone macroH2A1; histone macroH2A1.1; histone macroH2A1.2; medulloblastoma antigen MU-MB-50.205; unnamed protein product
Gene Aliases: H2A.y; H2A/y; H2AF12M; H2AFY; MACROH2A1.1; macroH2A1.2; mH2A1
UniProt ID: (Human) O75367
Entrez Gene ID: (Human) 9555
rDNA binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
chromatin binding
protein binding
double-stranded methylated DNA binding
enzyme binding
protein kinase binding
protein serine/threonine kinase inhibitor activity
structural constituent of chromatin
chromatin DNA binding
nucleosomal DNA binding
protein heterodimerization activity
ADP-D-ribose binding
ADP-D-ribose modification-dependent protein binding
poly-ADP-D-ribose modification-dependent protein binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
regulation of oxidative phosphorylation
DNA repair
nucleosome assembly
dosage compensation by inactivation of X chromosome
regulation of lipid metabolic process
heterochromatin assembly
positive regulation of maintenance of mitotic sister chromatid cohesion
regulation of gene expression, epigenetic
positive regulation of keratinocyte differentiation
negative regulation of gene expression, epigenetic
positive regulation of gene expression, epigenetic
regulation of chromatin silencing at rDNA
establishment of protein localization to chromatin
negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
regulation of NAD metabolic process
negative regulation of cell cycle G2/M phase transition
regulation of response to oxidative stress
negative regulation of response to oxidative stress
positive regulation of response to oxidative stress
positive regulation of endodermal cell differentiation
negative regulation of protein localization to chromosome, telomeric region
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support