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Invitrogen
JRK Polyclonal Antibody
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Product Details
PA5-65735
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human JRK. Recombinant protein control fragment (Product #RP-106407).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LELVKEGSSCP GQLRQRQAAS WGVAGREAEG GRPPAATSPA EVVWSSEKTP KADQDGGGDP GEGEEVAWEQ AAVAFDAVLR FAERQPCFSA
Highest antigen sequence identity to the following orthologs - mouse 45%, rat 46%.
Target Information
The JRK gene encodes a protein known as JRK (Jerky) homolog, which is implicated in various cellular processes, including DNA damage response and transcription regulation. JRK is conserved across multiple species and plays a role in the stability of neuronal functions and development. It is notably associated with neuropsychiatric disorders, where aberrations in its expression or function can contribute to conditions such as epilepsy and intellectual disabilities. The protein interacts with other cellular components to influence gene expression patterns, which are critical for maintaining normal neuronal activity. JRK is also studied for its potential involvement in cancer biology, where it may impact cell cycle regulation and genomic stability. Understanding the functions and mechanisms of JRK can provide insights into its roles in both normal physiological processes and disease states, particularly in the context of the nervous system and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: jerky homolog; Jerky protein homolog; Jrk homolog
Gene Aliases: jerky; JH8; JRK
UniProt ID: (Human) O75564
Entrez Gene ID: (Human) 8629
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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