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Invitrogen
GADD45A Polyclonal Antibody
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Product Details
PA5-65786
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human GADD45A. Recombinant protein control fragment (Product #RP-106462).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MTLEEFSAGEQ KTERMDKVGD ALEEVLSKAL SQ
Highest antigen sequence identity to the following orthologs - mouse 91%, rat 88%.
Target Information
GADD45 alpha, beta and gamma are an evolutionarily conserved, homologous family of nuclear proteins that function as stress sensors for cellular physiological and environmental damage. GADD45 proteins are required for the activation of the G2/M checkpoint induced by UV radiation or alkylating agents. GADD45-induced G2/M checkpoint is regulated through inactivation of Cdc2-cyclin B1 kinase. GADD45 forms a complex with p21 and Cdc2, and may serve as core for interaction with other cell cycle regulators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DDIT 1; DDIT-1; DNA damage-inducible transcript 1 protein; DNA damage-inducible transcript-1; DNA-damage-inducible transcript 1; Growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible 45 alpha; growth arrest and DNA-damage-inducible, alpha
Gene Aliases: DDIT1; GADD45; GADD45A
UniProt ID: (Human) P24522
Entrez Gene ID: (Human) 1647
regulation of cyclin-dependent protein serine/threonine kinase activity
G2/M transition of mitotic cell cycle
activation of MAPKKK activity
DNA repair
negative regulation of protein kinase activity
apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell cycle arrest
centrosome cycle
signal transduction in response to DNA damage
positive regulation of apoptotic process
positive regulation of JNK cascade
cellular response to mechanical stimulus
cellular response to ionizing radiation
mitotic cell cycle arrest
positive regulation of p38MAPK cascade
positive regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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