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Invitrogen
HYD Polyclonal Antibody
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Product Details
PA5-65815
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human HYD. Recombinant protein control fragment (Product #RP-106488).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GSTSKEGEPNL DKKNTPVQSP VSLGEDLQWW PDKDGTKFIC IGALYSELLA VSSKGELYQW KWSESEPYRN AQNPSLHHPR ATFLGLTNEK I
Highest antigen sequence identity to the following orthologs - mouse 97%, rat 60%.
Target Information
EDD (for E3 identified by Differential Display) is a progestin-regulated gene that was isolated from T-47D human breast cancer cells. Based on sequence homology, EDD appears to be a human homolog of the Drosophila hyperplastic discs (hyd) gene, a tumor suppressor gene that is required for control of imaginal disc growth. EDD contains a HECT domain in the carboxy terminus. HECT domain-containing proteins function as ubiquitin-protein ligases, or E3 enzymes. EDD has been shown to bind to ubiquitin, and like other HECT family proteins, may function as an E3 ubiquitin-protein ligase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CH D1S3362; E3 identified by differential display; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; ECGF1; EDG-1; EDG1; HECT E3; ubiquitin-protein ligase; HECT-type E3 ubiquitin transferase UBR5; hHYD; Hyperplastic discs protein homolog; Progestin-induced protein; S1P receptor 1; S1P receptor Edg-1; S1P1; S1PR1; unnamed protein product
Gene Aliases: DD5; EDD; EDD1; HYD; KIAA0896; UBR5
UniProt ID: (Human) O95071
Entrez Gene ID: (Human) 51366
protein polyubiquitination
DNA repair
cellular response to DNA damage stimulus
response to oxidative stress
proteasomal protein catabolic process
positive regulation of gene expression
protein ubiquitination
intracellular estrogen receptor signaling pathway
negative regulation of extent of heterochromatin assembly
protein K29-linked ubiquitination
positive regulation of protein import into nucleus
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of smoothened signaling pathway
retinoic acid receptor signaling pathway
progesterone receptor signaling pathway
vitamin D receptor signaling pathway
protein K48-linked ubiquitination
protein K11-linked ubiquitination
cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
positive regulation of canonical Wnt signaling pathway
cytoplasm protein quality control
DNA repair-dependent chromatin remodeling
protein branched polyubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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