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Invitrogen
KANK1 Polyclonal Antibody
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Product Details
PA5-65999
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human KANK1. Recombinant protein control fragment (Product #RP-106684).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: APLGMMTGLDH YIERIQKLLA EQQTLLAENY SELAEAFGEP HSQMGSLNSQ LISTLSSINS VMKSASTEEL RNPDFQKTSL GKITGNYLGY TCKCGGLQSG SPLSSQTSQP EQEVGTSEGK PISSLDAFPT QEGTLSPVNL TDDQ
Highest antigen sequence identity to the following orthologs - mouse 77%, rat 79%.
Target Information
Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. KANK1 (KN motif and ankyrin repeat domain-containing protein 1), also known as ANKRD15, is a 1,352 amino acid protein that contains at least 12 exons and 5 ANK repeats. It binds to beta-catenin and regulates its subcellular distribution. KANK1 is ubiquitously expressed and localizes to cytoplasm. It may function as a tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ankyrin repeat domain-containing protein 15; KIAA0172; Kidney ankyrin repeat-containing protein; KN motif and ankyrin repeat domain-containing protein 1; unnamed protein product
Gene Aliases: ANKRD15; CPSQ2; KANK; KANK1; KIAA0172
UniProt ID: (Human) Q14678
Entrez Gene ID: (Human) 23189
cell proliferation
negative regulation of neuron projection development
actin cytoskeleton organization
positive regulation of Wnt signaling pathway
negative regulation of cell migration
negative regulation of actin filament polymerization
regulation of Rho protein signal transduction
negative regulation of Rho protein signal transduction
cortical microtubule organization
negative regulation of insulin receptor signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of wound healing
glomerular visceral epithelial cell migration
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of ruffle assembly
regulation of establishment of cell polarity
negative regulation of lamellipodium morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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