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Invitrogen
SETX Polyclonal Antibody
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Product Details
PA5-66071
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human SETX. Recombinant protein control fragment (Product #RP-106760).
Conjugate
Form
Liquid
Concentration
0.30 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DTTNYKSYWLG ICMLLTILEE QAMDSLLLGS DKQNDFMQSI LHTMEREADD DSVDPFWPAL HCFMVILDRL GSKVWGQLMD PIVAFQTIIN NASYNREIRH IRNSSVRTKL EPESYLDDMV TCSQIV
Highest antigen sequence identity to the following orthologs - mouse 89%, rat 89%.
Target Information
Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation. Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amyotrophic lateral sclerosis 4 protein; Helicase senataxin; SEN1 homolog; Senataxin; senataxin; SEN1; DEAxQ-box helicase; tRNA splicing endonuclease regulator 1; unnamed protein product
Gene Aliases: ALS4; AOA2; bA479K20.2; KIAA0625; SCAN2; SCAR1; Sen1; SETX; STEX
UniProt ID: (Human) Q7Z333
Entrez Gene ID: (Human) 23064
DNA repair
double-strand break repair
DNA recombination
DNA-templated transcription, termination
termination of RNA polymerase II transcription
mRNA splice site selection
RNA processing
cellular response to DNA damage stimulus
spermatogenesis
nervous system development
circadian rhythm
positive regulation of neuron projection development
cell differentiation
positive regulation of RNA splicing
cellular response to oxidative stress
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
positive regulation of DNA-templated transcription, termination
cellular response to hydrogen peroxide
positive regulation of DNA-templated transcription, initiation
positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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