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Invitrogen
Growth Hormone Receptor Polyclonal Antibody
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FIGURE: 1 / 1
Growth Hormone Receptor Antibody (PA5-66102) in ICC/IF
Immunofluorescent staining of Growth Hormone Receptor in human cell line U-2 OS shows localization to plasma membrane, cytosol and cytoplasmic bodies. Samples were probed using a Growth Hormone Receptor Polyclonal Antibody (Product # PA5-66102).
Product Details
PA5-66102
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Growth Hormone Receptor. Recombinant protein control fragment (Product #RP-105082).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KEPKFTKCRSP ERETFSCHWT DEVHHGTKNL GPIQLFYTRR NTQEWTQEWK ECPDYVSAGE NSCYFNSSFT SIWIPYCIKL TSNGGTVDEK CFSVDEIVQP DPP
Highest antigen sequence identity to the following orthologs - mouse 68%, rat 74%.
Target Information
Growth hormone receptor (GHR) is a gene located on chromosome 5p13.1, encoding a transmembrane receptor that plays a critical role in mediating the effects of growth hormone, which is crucial for growth, metabolism, and tissue development. GHR is expressed in various tissues, including the liver, muscle, and adipose tissue, and facilitates the growth hormone signaling pathway by binding to growth hormone, leading to receptor dimerization and activation of intracellular signaling cascades such as the JAK2-STAT5 pathway. This signaling promotes growth and anabolic processes, influencing body composition, insulin sensitivity, and lipid metabolism. Mutations or alterations in the GHR gene can lead to growth disorders like Laron syndrome, characterized by insensitivity to growth hormone. Understanding GHR's structure and function is pivotal for developing therapeutic strategies for growth deficiencies and metabolic syndromes, as modifying GHR signaling pathways can offer potential interventions in related conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GH receptor; growth hormone binding protein; Growth hormone receptor; MGC124963; MGC156665; mutant growth hormone receptor; serum binding protein; Somatotropin receptor; unnamed protein product
Gene Aliases: GHBP; GHIP; GHR
UniProt ID: (Human) P10912
Entrez Gene ID: (Human) 2690
cytokine receptor activity
growth hormone receptor activity
protein binding
lipid binding
peptide hormone binding
growth factor binding
protein kinase binding
protein phosphatase binding
cytokine binding
protein tyrosine kinase activator activity
SH2 domain binding
identical protein binding
protein homodimerization activity
proline-rich region binding
protein tyrosine kinase binding
endocytosis
JAK-STAT cascade
positive regulation of cell proliferation
response to gravity
response to hormone
hormone-mediated signaling pathway
cytokine-mediated signaling pathway
taurine metabolic process
receptor internalization
response to food
regulation of response to nutrient levels
response to estradiol
cellular response to insulin stimulus
cellular response to hormone stimulus
response to cytokine
regulation of multicellular organism growth
positive regulation of multicellular organism growth
hormone metabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of MAPK cascade
response to peptide hormone
positive regulation of cell differentiation
positive regulation of JAK-STAT cascade
response to cycloheximide
insulin-like growth factor receptor signaling pathway
response to glucocorticoid
cartilage development involved in endochondral bone morphogenesis
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
negative regulation of growth hormone receptor signaling pathway
response to growth hormone
response to interleukin-1
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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