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Invitrogen
NKG2C Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-66127
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human NKG2C. Recombinant protein control fragment (Product #RP-105632).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CAVLQVNRLKS AQCGSSMIYH CKH
Highest antigen sequence identity to the following orthologs - mouse 38%, rat 38%.
Target Information
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD159 antigen-like family member C; CD159A; cd159e; killer cell lectin-like receptor subfamily C, member 2; KLRC1; natural killer cell receptor G2-C; NK cell receptor C; NKG2; NKG2-C gene; NKG2-C-activating NK receptor; NKG2A; unnamed protein product
Gene Aliases: CD159c; NKG2-C; NKG2C
UniProt ID: (Human) P26717
Entrez Gene ID: (Human) 3822
stimulatory C-type lectin receptor signaling pathway
natural killer cell mediated immunity
immune system process
immune response-regulating cell surface receptor signaling pathway
cellular defense response
signal transduction
regulation of natural killer cell activation
regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell degranulation
positive regulation of natural killer cell mediated cytotoxicity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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