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Invitrogen
XDH Polyclonal Antibody
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Product Details
PA5-66510
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human XDH. Recombinant protein control fragment (Product #RP-107180).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GFVCFISADDV PGSNITGICN DETVFAKDKV TCVGHIIGAV VADTPEHTQR AAQGVKITYE ELPAIITIED AIKNNSFYGP ELKIEKGDLK K
Highest antigen sequence identity to the following orthologs - mouse 87%, rat 84%.
Target Information
XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Xanthine dehydrogenase/oxidase; xanthine oxidoreductase; xdh antibody; xdha antibody; xor antibody
Gene Aliases: XAN1; XDH; XDHA; XO; XOR
UniProt ID: (Human) P47989
Entrez Gene ID: (Human) 7498
xanthine dehydrogenase activity
xanthine oxidase activity
iron ion binding
protein binding
oxidoreductase activity
protein homodimerization activity
molybdopterin cofactor binding
metal ion binding
flavin adenine dinucleotide binding
iron-sulfur cluster binding
2 iron, 2 sulfur cluster binding
hypoxanthine dehydrogenase activity
hypoxanthine oxidase activity
FAD binding
allantoin metabolic process
guanine catabolic process
inosine catabolic process
deoxyinosine catabolic process
adenosine catabolic process
deoxyadenosine catabolic process
deoxyguanosine catabolic process
AMP catabolic process
IMP catabolic process
lactation
hypoxanthine catabolic process
xanthine catabolic process
iron-sulfur cluster assembly
regulation of epithelial cell differentiation
cellular amide catabolic process
GMP catabolic process
dGMP catabolic process
dAMP catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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