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Invitrogen
MEL18 Polyclonal Antibody
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Product Details
PA5-66592
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human MEL18. Recombinant protein control fragment (Product #RP-107245).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PSEGTNTSGAS ECESVSDKAP SPATLPATSS SLPSPATPSH GS
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
Target Information
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-binding protein Mel-18; MGC10545; Polycomb group RING finger protein 2; RING finger protein 110; Zinc finger protein 144
Gene Aliases: MEL-18; MEL18; PCGF2; RNF110; TPFS; ZNF144
UniProt ID: (Human) P35227
Entrez Gene ID: (Human) 7703
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
chromatin organization
chromatin remodeling
anterior/posterior pattern specification
embryonic skeletal system morphogenesis
embryonic skeletal system development
cellular response to hydrogen peroxide
apoptotic signaling pathway
negative regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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