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Invitrogen
TMEM8A Polyclonal Antibody
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Product Details
PA5-66706
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human TMEM8A. Recombinant protein control fragment (Product #RP-107355).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PFLGFNTSLNC TTAFFQGYPL SLSAWSRRAN LIIPYPETDN WYLSLQLMCP ENAEDCEQAV VHVETTLYLV PC
Highest antigen sequence identity to the following orthologs - mouse 81%, rat 82%.
Target Information
Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: five-span transmembrane protein M83; GPI processing phospholipase A2; GPI-PLA2; Post-GPI attachment to proteins factor 6; Protein M83; Transmembrane protein 6; Transmembrane protein 8; transmembrane protein 8 (five membrane-spanning domains); Transmembrane protein 8A
Gene Aliases: M83; PGAP6; TMEM6; TMEM8; TMEM8A
UniProt ID: (Human) Q9HCN3
Entrez Gene ID: (Human) 58986
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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