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Invitrogen
SEMA5B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-66850
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human SEMA5B. Recombinant protein control fragment (Product #RP-107506).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QESTLVHPATP NHLHYKGGGT PKNEKYTPME FKTLNKNNLI PDDRANFYPL QQTNVYTTTY YPSPLNKHSF RPEASPGQRC FPN
Highest antigen sequence identity to the following orthologs - mouse 99%, rat 90%.
Target Information
Semaphorin 5B (SEMA5B) is a gene belonging to the Semaphorin family, which is known for its role as guidance cues in various biological processes. The gene is located on chromosome 3q21.3 and encodes for the transmembrane protein Semaphorin 5B, which participates significantly in neural development and cancer processes. SEMA5B serves as a guidance cue in neural tissues, impacting axonal growth and branching by acting through receptors like PlexinA1. It is proteolytically processed from its transmembrane form to a soluble form, capable of collapsing growth cones in neurons, thereby regulating neuronal pathfinding. Studies have revealed that SEMA5B impacts sensory afferent projections through interactions with cell adhesion molecules such as TAG-1. Moreover, SEMA5B has been implicated in cancer, particularly showing upregulated expression in kidney renal clear cell carcinoma (KIRC) at both mRNA and protein levels. Its expression correlates with various clinical parameters, including tumor stage and patient demographics. Its dynamic expression pattern in the spinal cord suggests a role in the modulation of sensory axon growth, further emphasizing its importance in developmental neurobiology and pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B; unnamed protein product
Gene Aliases: SEMAG; SemG
UniProt ID: (Human) Q9P283
Entrez Gene ID: (Human) 54437
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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