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Invitrogen
UPF2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-66888
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human UPF2. Recombinant protein control fragment (Product #RP-107535).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LTRKGNKQQFK ILNVPMSSQL AANHWNQQQA EQEERMRMKK LTLDINERQE QEDYQEMLQS LAQRPAPANT NRERRPRYQH PKGAPNADLI FKTGG
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 92%.
Target Information
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FRS2/UPF2/LEMD3 fusion; involved in NMD pathway; LEMD3/UPF2 fusion; nonsense mRNA reducing factor 2; smg-3 homolog, nonsense mediated mRNA decay factor; unnamed protein product; up-frameshift suppressor 2 homolog; UPF2 regulator of nonsense transcripts homolog; yeast Upf2p homolog
Gene Aliases: HUPF2; RENT2; smg-3
UniProt ID: (Human) Q9HAU5
Entrez Gene ID: (Human) 26019
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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