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Invitrogen
RTEL1 Polyclonal Antibody
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Product Details
PA5-66911
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human RTEL1. Recombinant protein control fragment (Product #RP-105423).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PKKHNLLQGFY QFVRPHHKQQ FEEVCIQLTG RGCGYRPEHS IPRRQRAQPV LDPTGRTAPD PKLTVSTAAA QQLDPQEHLN QG
Highest antigen sequence identity to the following orthologs - mouse 53%, rat 60%.
Target Information
ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Novel helicase-like; Regulator of telomere elongation helicase 1; regulator of telomere length; unnamed protein product
Gene Aliases: C20orf41; DKCA4; DKCB5; KIAA1088; NHL; PFBMFT3; RTEL; RTEL1
UniProt ID: (Human) Q9NZ71
Entrez Gene ID: (Human) 51750
nucleotide binding
nucleic acid binding
DNA binding
DNA helicase activity
helicase activity
protein binding
ATP binding
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
isomerase activity
ATPase activity
metal ion binding
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
DNA polymerase binding
regulation of DNA recombination
telomere maintenance
strand displacement
nucleobase-containing compound metabolic process
DNA replication
DNA repair
DNA recombination
cellular response to DNA damage stimulus
regulation of double-strand break repair via homologous recombination
replication fork processing
positive regulation of telomere maintenance
telomere maintenance in response to DNA damage
negative regulation of DNA recombination
regulation of cellular response to stress
telomeric loop disassembly
mitotic telomere maintenance via semi-conservative replication
positive regulation of telomere capping
positive regulation of telomere maintenance via telomere lengthening
negative regulation of t-circle formation
negative regulation of telomere maintenance in response to DNA damage
positive regulation of telomeric loop disassembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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