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Invitrogen
PICK1 Polyclonal Antibody
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Product Details
PA5-66915
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human PICK1. Recombinant protein control fragment (Product #RP-107567).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LTIKKYLDVKF EYLSYCLKVK EMDDEEYSCI ALGEPLYRVS TGNYEYRLIL RCRQEARARF SQMRKDVLEK MELLD
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
Target Information
PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCalpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCalpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCalpha to membrane anchored GluR2. Once phosphorylated by PKCalpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC15204; OTTHUMP00000028509; PRKCA-binding protein; PRKCABP; Protein interacting with C kinase 1; Protein kinase C-alpha-binding protein; unnamed protein product
Gene Aliases: PICK; PICK1; PRKCABP
UniProt ID: (Human) Q9NRD5
Entrez Gene ID: (Human) 9463
positive regulation of receptor internalization
protein phosphorylation
intracellular protein transport
monoamine transport
glial cell development
regulation of Arp2/3 complex-mediated actin nucleation
negative regulation of Arp2/3 complex-mediated actin nucleation
cellular response to decreased oxygen levels
cellular response to glucose starvation
receptor clustering
neuronal ion channel clustering
regulation of insulin secretion
long term synaptic depression
dendritic spine organization
dendritic spine maintenance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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